Dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), mosquito-borne diseases, are caused by dengue virus (DENV) infection. During the infection, human immune response plays an important role in the disease development and severity. One of the host immune response is a massive cytokine production to be known as DENV-initiated “cytokine storm”. Currently, there is no licensed vaccine or specific antiviral drug for prevention and treatment of DENV infection. Therefore, the search for anti-DENV infection and anti-inflammatory compounds that will be able to cure or alleviate the DENV-associated diseases is urgently required. In this study, we aim to investigate the Namibian plant (Salsola tuberculatiformis) extracted, compound A (CpdA) - a phenyl aziridine precursor, on cytokine expression in DENV infected cells. CpdA can modulate cytokine gene expression through directly binding to glucocorticoid receptor. Thus, dexamethasone (DEX) - a corticosteroid, was also used as a control for anti-inflammatory studies. Human lung epithelial carcinoma (A549) cells were infected with DENV2 at MOI 5; then, the mRNA levels of TNF-a, IL-6, IP-10, and RANTES were determined by real-time PCR and normalized against mRNA level of GAPDH by using a comparative Ct (delta delta Ct) method. The elevations of TNF-a, IL-6, IP-10, and RANTES mRNA expression were observed in DENV-infected A549 cells. DEX and CpdA similarly reduced about half of TNF-a, IL-6, IP-10, and RANTES expression in DENV-infected cells. The anti-inflammatory effect of CpdA in DENV-infected cells as found in the present study suggests its potentially therapeutic benefit, which warrants further investigation.